We don't celebrate thanksgiving from where I am, but it's a nice reminder to be thankful for the things we have in this life.
Me? I'm thankful for my family, friends and where I am at this point in time, artistically, and professionally. EDIT
: Made some major booboos. Corrected Marcy's eyes on the 2nd panel so they're consistent with the rest of the comic. Same with the other characters.